Kaiser Permanente--comprising the Kaiser Foundation Health Plan, Kaiser Foundation Hospitals, and Permanente Medical Groups in eight regions--is the largest nonprofit integrated health care delivery system in the United States. The successful evolution of this organizational structure in a competitive marketplace has required a close partnership between managers and physicians supported by a culture of physician group accountability for quality and efficiency. An overarching agenda for achieving excellence focuses on high-impact health conditions, provides goal-oriented tools to analyze population data, proactively identifies patients in need of intervention, supports systematic process improvements, and promotes collaboration between patients and professionals to improve health. Central to this effort is KP HealthConnect, a comprehensive health information system that integrates an electronic health record with the tools to support physicians in delivering evidence-based medicine, coupled with a robust online patient portal that enhances members’ access to and involvement in their care.